PE-22-28

PE-22-28 is an advanced neuropeptide composed of the amino acid sequence GVSWGLR (Gly-Val-Ser-Trp-Gly-Leu-Arg). Developed as a shortened and more potent analog of spadin, it has attracted significant interest in neuroscience research due to its selective inhibition of the TREK-1 potassium channel, a target associated with mood regulation, neuroplasticity, and neuronal survival.

Preclinical studies suggest that PE-22-28 may promote rapid neurogenesis, enhance synaptic plasticity, and support cognitive function. Researchers have investigated its potential applications in depression models, neuroprotection, stroke recovery, and brain health. Unlike traditional antidepressant mechanisms, PE-22-28 acts through modulation of neuronal ion channels, making it a unique compound within the neuropeptide research field.

Due to limited human clinical data, PE-22-28 remains an investigational compound. Current research continues to explore its pharmacological properties, safety profile, and potential therapeutic applications. It is commonly supplied as a lyophilized powder for laboratory and scientific research purposes.